Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis

Conceição M P S de Azevedo; Renata R Gomes; Vania A Vicente; Daniel W C L Santos; Sirlei G Marques; Mariana M F do Nascimento; Caroline E W Andrade; Raimunda R Silva; Flávio Queiroz-Telles; G Sybren de Hoog

doi:10.1128/JCM.00637-15

Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis

Conceição M P S de Azevedo, Renata R Gomes, Vania A Vicente, Daniel W C L Santos, Sirlei G Marques, Mariana M F do Nascimento, Caroline E W Andrade, Raimunda R Silva, Flávio Queiroz-Telles, G Sybren de Hoog

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Abstract

We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain.

Original language	English
Pages (from-to)	2674-85
Number of pages	12
Journal	Journal of Clinical Microbiology
Volume	53
Issue number	8
DOIs	https://doi.org/10.1128/JCM.00637-15
Publication status	Published - Aug 2015

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title = "Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis",

abstract = "We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain.",

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year = "2015",

month = aug,

doi = "10.1128/JCM.00637-15",

language = "English",

volume = "53",

pages = "2674--85",

journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

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T1 - Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis

AU - de Azevedo, Conceição M P S

AU - Gomes, Renata R

AU - Vicente, Vania A

AU - Santos, Daniel W C L

AU - Marques, Sirlei G

AU - do Nascimento, Mariana M F

AU - Andrade, Caroline E W

AU - Silva, Raimunda R

AU - Queiroz-Telles, Flávio

AU - de Hoog, G Sybren

PY - 2015/8

Y1 - 2015/8

N2 - We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain.

AB - We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain.

U2 - 10.1128/JCM.00637-15

DO - 10.1128/JCM.00637-15

M3 - Article

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SN - 0095-1137

VL - 53

SP - 2674

EP - 2685

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 8

ER -

Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis

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