For genomes to stay in shape, insulators must be up to PAR

P.J. Wijchers; W. de Laat

doi:10.1016/j.cell.2013.09.012

For genomes to stay in shape, insulators must be up to PAR

P.J. Wijchers, W. de Laat

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

Original language	English
Pages (from-to)	15-16
Journal	Cell
Volume	155
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2013.09.012
Publication status	Published - 2013

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10.1016/j.cell.2013.09.012

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title = "For genomes to stay in shape, insulators must be up to PAR",

abstract = "Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.",

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AB - Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

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For genomes to stay in shape, insulators must be up to PAR

Abstract

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