Four-dimensional computational ultrasound imaging of brain hemodynamics

Michael D Brown, Bastian S Generowicz, Stephanie Dijkhuizen, Sebastiaan K E Koekkoek, Christos Strydis, Johannes G Bosch, Petros Arvanitis, Geert Springeling, Geert J T Leus, Chris I De Zeeuw, Pieter Kruizinga

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), an imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain hemodynamics in awake and anesthetized mice.

Original languageEnglish
Pages (from-to)eadk7957
JournalScience advances
Issue number3
Publication statusPublished - 19 Jan 2024


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