From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells

Saskia J E Suijkerbuijk; Jacco van Rheenen

doi:10.1016/j.ydbio.2017.04.015

From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells

Saskia J E Suijkerbuijk, Jacco van Rheenen

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

17 Citations (Scopus)

Abstract

Homeostasis of tissues is tightly regulated at the cellular, tissue and organismal level. Interestingly, tumor cells have found ways to hijack many of these physiological processes at all the different levels. Here we review how intravital microscopy techniques have provided new insights into our understanding of tissue homeostasis and cancer progression. In addition, we highlight the different strategies that tumor cells have adopted to use these physiological processes for their own benefit. We describe how visualization of these dynamic processes in living mice has broadened to our view on cancer initiation and progression.

Original language	English
Pages (from-to)	328-337
Number of pages	10
Journal	Developmental Biology
Volume	428
Issue number	2
DOIs	https://doi.org/10.1016/j.ydbio.2017.04.015
Publication status	Published - 15 Aug 2017

Keywords

Adult Stem Cells
Animals
Cell Communication
Cell Movement
Disease Progression
Humans
Inflammation
Intravital Microscopy
Neoplasms
Neoplastic Stem Cells
Neovascularization, Pathologic
Stem Cell Niche
Tumor Microenvironment
Wound Healing
Journal Article
Review
Research Support, Non-U.S. Gov't

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10.1016/j.ydbio.2017.04.015

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title = "From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells",

abstract = "Homeostasis of tissues is tightly regulated at the cellular, tissue and organismal level. Interestingly, tumor cells have found ways to hijack many of these physiological processes at all the different levels. Here we review how intravital microscopy techniques have provided new insights into our understanding of tissue homeostasis and cancer progression. In addition, we highlight the different strategies that tumor cells have adopted to use these physiological processes for their own benefit. We describe how visualization of these dynamic processes in living mice has broadened to our view on cancer initiation and progression.",

keywords = "Adult Stem Cells, Animals, Cell Communication, Cell Movement, Disease Progression, Humans, Inflammation, Intravital Microscopy, Neoplasms, Neoplastic Stem Cells, Neovascularization, Pathologic, Stem Cell Niche, Tumor Microenvironment, Wound Healing, Journal Article, Review, Research Support, Non-U.S. Gov't",

author = "Suijkerbuijk, {Saskia J E} and {van Rheenen}, Jacco",

year = "2017",

month = aug,

day = "15",

doi = "10.1016/j.ydbio.2017.04.015",

language = "English",

volume = "428",

pages = "328--337",

journal = "Developmental Biology",

issn = "0012-1606",

publisher = "Academic Press",

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TY - JOUR

T1 - From good to bad

T2 - Intravital imaging of the hijack of physiological processes by cancer cells

AU - Suijkerbuijk, Saskia J E

AU - van Rheenen, Jacco

PY - 2017/8/15

Y1 - 2017/8/15

N2 - Homeostasis of tissues is tightly regulated at the cellular, tissue and organismal level. Interestingly, tumor cells have found ways to hijack many of these physiological processes at all the different levels. Here we review how intravital microscopy techniques have provided new insights into our understanding of tissue homeostasis and cancer progression. In addition, we highlight the different strategies that tumor cells have adopted to use these physiological processes for their own benefit. We describe how visualization of these dynamic processes in living mice has broadened to our view on cancer initiation and progression.

AB - Homeostasis of tissues is tightly regulated at the cellular, tissue and organismal level. Interestingly, tumor cells have found ways to hijack many of these physiological processes at all the different levels. Here we review how intravital microscopy techniques have provided new insights into our understanding of tissue homeostasis and cancer progression. In addition, we highlight the different strategies that tumor cells have adopted to use these physiological processes for their own benefit. We describe how visualization of these dynamic processes in living mice has broadened to our view on cancer initiation and progression.

KW - Adult Stem Cells

KW - Animals

KW - Cell Communication

KW - Cell Movement

KW - Disease Progression

KW - Humans

KW - Inflammation

KW - Intravital Microscopy

KW - Neoplasms

KW - Neoplastic Stem Cells

KW - Neovascularization, Pathologic

KW - Stem Cell Niche

KW - Tumor Microenvironment

KW - Wound Healing

KW - Journal Article

KW - Review

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ydbio.2017.04.015

DO - 10.1016/j.ydbio.2017.04.015

M3 - Article

C2 - 28473106

SN - 0012-1606

VL - 428

SP - 328

EP - 337

JO - Developmental Biology

JF - Developmental Biology

IS - 2

ER -

From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells

Abstract

Keywords

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