Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex

J. Dudok, Pim E G Leonards, J. Wijnholds

Research output: Contribution to journal/periodicalArticleScientificpeer-review

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Abstract

The migration of neuronal cells in the developing cerebral cortex is essential for proper development of the brain and brain networks. Disturbances in this process, due to genetic abnormalities or exogenous factors, leads to aberrant brain formation, brain network formation, and brain function. In the last decade, there has been extensive research in the field of neuronal migration. In this review, we describe different methods and approaches to assess and study neuronal migration in the developing cerebral cortex. First, we discuss several genetic methods, techniques and genetic models that have been used to study neuronal migration in the developing cortex. Second, we describe several molecular approaches to study aberrant neuronal migration in the cortex which can be used to elucidate the underlying mechanisms of neuronal migration. Finally, we describe model systems to investigate and assess the potential toxicity effect of prenatal exposure to environmental chemicals on proper brain formation and neuronal migration.

Original languageEnglish
Article numberE53
JournalBrain Sciences
Volume7
Issue number5
DOIs
Publication statusPublished - 2017

Keywords

  • Journal Article
  • Review

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