Genomics and the making of yeast biodiversity

Chris Todd Hittinger; Antonis Rokas; Feng-Yan Bai; Teun Boekhout; Paula Gonçalves; Thomas W Jeffries; Jacek Kominek; Marc-André Lachance; Diego Libkind; Carlos A Rosa; José Paulo Sampaio; Cletus P Kurtzman

doi:10.1016/j.gde.2015.10.008

Genomics and the making of yeast biodiversity

Chris Todd Hittinger, Antonis Rokas, Feng-Yan Bai, Teun Boekhout, Paula Gonçalves, Thomas W Jeffries, Jacek Kominek, Marc-André Lachance, Diego Libkind, Carlos A Rosa, José Paulo Sampaio, Cletus P Kurtzman

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

Abstract

Yeasts are unicellular fungi that do not form fruiting bodies. Although the yeast lifestyle has evolved multiple times, most known species belong to the subphylum Saccharomycotina (syn. Hemiascomycota, hereafter yeasts). This diverse group includes the premier eukaryotic model system, Saccharomyces cerevisiae; the common human commensal and opportunistic pathogen, Candida albicans; and over 1000 other known species (with more continuing to be discovered). Yeasts are found in every biome and continent and are more genetically diverse than angiosperms or chordates. Ease of culture, simple life cycles, and small genomes (∼10-20Mbp) have made yeasts exceptional models for molecular genetics, biotechnology, and evolutionary genomics. Here we discuss recent developments in understanding the genomic underpinnings of the making of yeast biodiversity, comparing and contrasting natural and human-associated evolutionary processes. Only a tiny fraction of yeast biodiversity and metabolic capabilities has been tapped by industry and science. Expanding the taxonomic breadth of deep genomic investigations will further illuminate how genome function evolves to encode their diverse metabolisms and ecologies.

Original language	English
Pages (from-to)	100-9
Number of pages	10
Journal	Current Opinion in Genetics & Development
Volume	35
DOIs	https://doi.org/10.1016/j.gde.2015.10.008
Publication status	Published - Dec 2015

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@article{d72b03a097f849da85494d8cd27ed697,

title = "Genomics and the making of yeast biodiversity",

abstract = "Yeasts are unicellular fungi that do not form fruiting bodies. Although the yeast lifestyle has evolved multiple times, most known species belong to the subphylum Saccharomycotina (syn. Hemiascomycota, hereafter yeasts). This diverse group includes the premier eukaryotic model system, Saccharomyces cerevisiae; the common human commensal and opportunistic pathogen, Candida albicans; and over 1000 other known species (with more continuing to be discovered). Yeasts are found in every biome and continent and are more genetically diverse than angiosperms or chordates. Ease of culture, simple life cycles, and small genomes (∼10-20Mbp) have made yeasts exceptional models for molecular genetics, biotechnology, and evolutionary genomics. Here we discuss recent developments in understanding the genomic underpinnings of the making of yeast biodiversity, comparing and contrasting natural and human-associated evolutionary processes. Only a tiny fraction of yeast biodiversity and metabolic capabilities has been tapped by industry and science. Expanding the taxonomic breadth of deep genomic investigations will further illuminate how genome function evolves to encode their diverse metabolisms and ecologies.",

author = "Hittinger, {Chris Todd} and Antonis Rokas and Feng-Yan Bai and Teun Boekhout and Paula Gon{\c c}alves and Jeffries, {Thomas W} and Jacek Kominek and Marc-Andr{\'e} Lachance and Diego Libkind and Rosa, {Carlos A} and Sampaio, {Jos{\'e} Paulo} and Kurtzman, {Cletus P}",

year = "2015",

month = dec,

doi = "10.1016/j.gde.2015.10.008",

language = "English",

volume = "35",

pages = "100--9",

journal = "Current Opinion in Genetics and Development",

issn = "0959-437X",

publisher = "Elsevier B.V.",

}

Genomics and the making of yeast biodiversity. / Hittinger, Chris Todd; Rokas, Antonis; Bai, Feng-Yan; Boekhout, Teun; Gonçalves, Paula; Jeffries, Thomas W; Kominek, Jacek; Lachance, Marc-André; Libkind, Diego; Rosa, Carlos A; Sampaio, José Paulo; Kurtzman, Cletus P.

In: Current Opinion in Genetics & Development, Vol. 35, 12.2015, p. 100-9.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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AU - Hittinger, Chris Todd

AU - Rokas, Antonis

AU - Bai, Feng-Yan

AU - Boekhout, Teun

AU - Gonçalves, Paula

AU - Jeffries, Thomas W

AU - Kominek, Jacek

AU - Lachance, Marc-André

AU - Libkind, Diego

AU - Rosa, Carlos A

AU - Sampaio, José Paulo

AU - Kurtzman, Cletus P

PY - 2015/12

Y1 - 2015/12

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