Getting the genome in shape: the formation of loops, domains and compartments

Britta Am Bouwman; Wouter de Laat

doi:10.1186/s13059-015-0730-1

Getting the genome in shape: the formation of loops, domains and compartments

Britta Am Bouwman, Wouter de Laat

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

85 Citations (Scopus)

Abstract

The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

Original language	English
Pages (from-to)	154
Journal	Genome Biology
Volume	16
DOIs	https://doi.org/10.1186/s13059-015-0730-1
Publication status	Published - 2015

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abstract = "The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.",

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Getting the genome in shape: the formation of loops, domains and compartments

Abstract

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