Glial origin of mesenchymal stem cells in a tooth model system

Nina Kaukua, Maryam Khatibi Shahidi, Chrysoula Konstantinidou, Vyacheslav Dyachuk, Marketa Kaucka, Alessandro Furlan, Zhengwen An, Longlong Wang, Isabell Hultman, Lars Ahrlund-Richter, Hans Blom, Hjalmar Brismar, Natalia Assaife Lopes, Vassilis Pachnis, Ueli Suter, Hans Clevers, Irma Thesleff, Paul Sharpe, Patrik Ernfors, Kaj FriedIgor Adameyko

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Mesenchymal stem cells occupy niches in stromal tissues where they provide sources of cells for specialized mesenchymal derivatives during growth and repair. The origins of mesenchymal stem cells have been the subject of considerable discussion, and current consensus holds that perivascular cells form mesenchymal stem cells in most tissues. The continuously growing mouse incisor tooth offers an excellent model to address the origin of mesenchymal stem cells. These stem cells dwell in a niche at the tooth apex where they produce a variety of differentiated derivatives. Cells constituting the tooth are mostly derived from two embryonic sources: neural crest ectomesenchyme and ectodermal epithelium. It has been thought for decades that the dental mesenchymal stem cells giving rise to pulp cells and odontoblasts derive from neural crest cells after their migration in the early head and formation of ectomesenchymal tissue. Here we show that a significant population of mesenchymal stem cells during development, self-renewal and repair of a tooth are derived from peripheral nerve-associated glia. Glial cells generate multipotent mesenchymal stem cells that produce pulp cells and odontoblasts. By combining a clonal colour-coding technique with tracing of peripheral glia, we provide new insights into the dynamics of tooth organogenesis and growth.

Original languageEnglish
Pages (from-to)551-4
Number of pages4
JournalNature
Volume513
Issue number7519
DOIs
Publication statusPublished - 25 Sep 2014

Keywords

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Tracking
  • Clone Cells
  • Dental Pulp
  • Female
  • Incisor
  • Male
  • Mesenchymal Stromal Cells
  • Mice
  • Models, Biological
  • Neural Crest
  • Neuroglia
  • Odontoblasts
  • Regeneration
  • Schwann Cells

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