Glucose-Sensing in the Reward System

Laura L. Koekkoek; Joram D. Mul; Susanne E. la Fleur

doi:10.3389/fnins.2017.00716

Glucose-Sensing in the Reward System

Laura L. Koekkoek, Joram D. Mul, Susanne E. la Fleur

Netherlands Institute for Neuroscience (NIN)

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Abstract

Glucose-sensing neurons are neurons that alter their activity in response to changes in extracellular glucose. These neurons, which are an important mechanism the brain uses to monitor changes in glycaemia, are present in the hypothalamus, where they have been thoroughly investigated. Recently, glucose-sensing neurons have also been identified in brain nuclei which are part of the reward system. However, little is known about the molecular mechanisms by which they function, and their role in the reward system. We therefore aim to provide an overview of molecular mechanisms that have been studied in
the hypothalamic glucose-sensing neurons, and investigate which of these transporters, enzymes and channels are present in the reward system. Furthermore, we speculate about the role of glucose-sensing neurons in the reward system.

Original language	English
Article number	716
Journal	Frontiers in Neuroscience
Volume	11
DOIs	https://doi.org/10.3389/fnins.2017.00716
Publication status	Published - 19 Dec 2017

Keywords

reward
nucleus accumbens
amygdala
SGLT
GLUT

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title = "Glucose-Sensing in the Reward System",

abstract = "Glucose-sensing neurons are neurons that alter their activity in response to changes in extracellular glucose. These neurons, which are an important mechanism the brain uses to monitor changes in glycaemia, are present in the hypothalamus, where they have been thoroughly investigated. Recently, glucose-sensing neurons have also been identified in brain nuclei which are part of the reward system. However, little is known about the molecular mechanisms by which they function, and their role in the reward system. We therefore aim to provide an overview of molecular mechanisms that have been studied inthe hypothalamic glucose-sensing neurons, and investigate which of these transporters, enzymes and channels are present in the reward system. Furthermore, we speculate about the role of glucose-sensing neurons in the reward system.",

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AB - Glucose-sensing neurons are neurons that alter their activity in response to changes in extracellular glucose. These neurons, which are an important mechanism the brain uses to monitor changes in glycaemia, are present in the hypothalamus, where they have been thoroughly investigated. Recently, glucose-sensing neurons have also been identified in brain nuclei which are part of the reward system. However, little is known about the molecular mechanisms by which they function, and their role in the reward system. We therefore aim to provide an overview of molecular mechanisms that have been studied inthe hypothalamic glucose-sensing neurons, and investigate which of these transporters, enzymes and channels are present in the reward system. Furthermore, we speculate about the role of glucose-sensing neurons in the reward system.

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KW - SGLT

KW - GLUT

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Glucose-Sensing in the Reward System

Abstract

Keywords

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