Handedness and depression: A meta-analysis across 87 studies

Julian Packheiser; Judith Schmitz; Clara C Stein; Lena Sophie Pfeifer; Gesa Berretz; Marietta Papadatou-Pastou; Jutta Peterburs; Sebastian Ocklenburg

doi:10.1016/j.jad.2021.07.052

Handedness and depression: A meta-analysis across 87 studies

Julian Packheiser, Judith Schmitz, Clara C Stein, Lena Sophie Pfeifer, Gesa Berretz, Marietta Papadatou-Pastou, Jutta Peterburs, Sebastian Ocklenburg

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

Alterations in functional brain lateralization, often indicated by an increased prevalence of left- and/or mixed-handedness, have been demonstrated in several psychiatric and neurodevelopmental disorders like schizophrenia or autism spectrum disorder. For depression, however, this relationship is largely unclear. While a few studies found evidence that handedness and depression are associated, both the effect size and the direction of this association remain elusive. Here, we collected data from 87 studies totaling 35,501 individuals to provide a precise estimate of differences in left-, mixed- and non-right-handedness between depressed and healthy samples and computed odds ratios (ORs) between these groups. Here, an OR > 1 signifies higher rates of atypical handedness in depressed compared to healthy samples. We found no differences in left- (OR = 1.04, 95% CI = [0.95, 1.15], p = .384), mixed- (OR = 1.64, 95% CI = [0.98, 2.74], p = .060) or non-right-handedness (OR = 1.05, 95% CI = [0.96, 1.15], p = .309) between the two groups. We could thus find no link between handedness and depression on the meta-analytical level.

Original language	English
Pages (from-to)	200-209
Number of pages	10
Journal	Journal of Affective Disorders
Volume	294
DOIs	https://doi.org/10.1016/j.jad.2021.07.052
Publication status	Published - 16 Jul 2021

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Packheiser et alAccepted author manuscript, 1.43 MBLicence: CC BY-NC-ND

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@article{5255a48f03154db090476497b2f666ba,

title = "Handedness and depression: A meta-analysis across 87 studies",

abstract = "Alterations in functional brain lateralization, often indicated by an increased prevalence of left- and/or mixed-handedness, have been demonstrated in several psychiatric and neurodevelopmental disorders like schizophrenia or autism spectrum disorder. For depression, however, this relationship is largely unclear. While a few studies found evidence that handedness and depression are associated, both the effect size and the direction of this association remain elusive. Here, we collected data from 87 studies totaling 35,501 individuals to provide a precise estimate of differences in left-, mixed- and non-right-handedness between depressed and healthy samples and computed odds ratios (ORs) between these groups. Here, an OR > 1 signifies higher rates of atypical handedness in depressed compared to healthy samples. We found no differences in left- (OR = 1.04, 95% CI = [0.95, 1.15], p = .384), mixed- (OR = 1.64, 95% CI = [0.98, 2.74], p = .060) or non-right-handedness (OR = 1.05, 95% CI = [0.96, 1.15], p = .309) between the two groups. We could thus find no link between handedness and depression on the meta-analytical level.",

author = "Julian Packheiser and Judith Schmitz and Stein, {Clara C} and Pfeifer, {Lena Sophie} and Gesa Berretz and Marietta Papadatou-Pastou and Jutta Peterburs and Sebastian Ocklenburg",

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doi = "10.1016/j.jad.2021.07.052",

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T2 - A meta-analysis across 87 studies

AU - Packheiser, Julian

AU - Schmitz, Judith

AU - Stein, Clara C

AU - Pfeifer, Lena Sophie

AU - Berretz, Gesa

AU - Papadatou-Pastou, Marietta

AU - Peterburs, Jutta

AU - Ocklenburg, Sebastian

PY - 2021/7/16

Y1 - 2021/7/16

N2 - Alterations in functional brain lateralization, often indicated by an increased prevalence of left- and/or mixed-handedness, have been demonstrated in several psychiatric and neurodevelopmental disorders like schizophrenia or autism spectrum disorder. For depression, however, this relationship is largely unclear. While a few studies found evidence that handedness and depression are associated, both the effect size and the direction of this association remain elusive. Here, we collected data from 87 studies totaling 35,501 individuals to provide a precise estimate of differences in left-, mixed- and non-right-handedness between depressed and healthy samples and computed odds ratios (ORs) between these groups. Here, an OR > 1 signifies higher rates of atypical handedness in depressed compared to healthy samples. We found no differences in left- (OR = 1.04, 95% CI = [0.95, 1.15], p = .384), mixed- (OR = 1.64, 95% CI = [0.98, 2.74], p = .060) or non-right-handedness (OR = 1.05, 95% CI = [0.96, 1.15], p = .309) between the two groups. We could thus find no link between handedness and depression on the meta-analytical level.

AB - Alterations in functional brain lateralization, often indicated by an increased prevalence of left- and/or mixed-handedness, have been demonstrated in several psychiatric and neurodevelopmental disorders like schizophrenia or autism spectrum disorder. For depression, however, this relationship is largely unclear. While a few studies found evidence that handedness and depression are associated, both the effect size and the direction of this association remain elusive. Here, we collected data from 87 studies totaling 35,501 individuals to provide a precise estimate of differences in left-, mixed- and non-right-handedness between depressed and healthy samples and computed odds ratios (ORs) between these groups. Here, an OR > 1 signifies higher rates of atypical handedness in depressed compared to healthy samples. We found no differences in left- (OR = 1.04, 95% CI = [0.95, 1.15], p = .384), mixed- (OR = 1.64, 95% CI = [0.98, 2.74], p = .060) or non-right-handedness (OR = 1.05, 95% CI = [0.96, 1.15], p = .309) between the two groups. We could thus find no link between handedness and depression on the meta-analytical level.

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DO - 10.1016/j.jad.2021.07.052

M3 - Article

C2 - 34298226

SN - 0165-0327

VL - 294

SP - 200

EP - 209

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Handedness and depression: A meta-analysis across 87 studies

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