Haplotype-based genetics in mice and rats

E. Cuppen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

29 Citations (Scopus)


Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.
Original languageEnglish
Pages (from-to)318-322
JournalTrends in Genetics
Issue number6
Publication statusPublished - 2005


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