Haplotype-based genetics in mice and rats

E. Cuppen

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.
Original languageEnglish
Pages (from-to)318-322
JournalTrends in Genetics
Volume21
Issue number6
DOIs
Publication statusPublished - 2005

Fingerprint

Dive into the research topics of 'Haplotype-based genetics in mice and rats'. Together they form a unique fingerprint.

Cite this