Healthy scents: microbial volatiles as new frontier in antibiotic research?

TY - JOUR

T1 - Healthy scents: microbial volatiles as new frontier in antibiotic research?

AU - Avalos Garcia, M.

AU - van Wezel, G.P.

AU - Raaijmakers, J.M.

AU - Garbeva, P.V.

N1 - 6496, ME; Data Archiving: no data review article

PY - 2018

Y1 - 2018

N2 - Microorganisms represent a large and still resourceful pool for the discovery of novel compounds to combat antibiotic resistance in human and animal pathogens. The ability of microorganisms to produce structurally diverse volatile compounds has been known for decades, yet their biological functions and antimicrobial activities have only recently attracted attention. Various studies revealed that microbial volatiles can act as infochemicals in long-distance cross-kingdom communication as well as antimicrobials in competition and predation. Here, we review recent insights into the natural functions and modes of action of microbial volatiles and discuss their potential as a new class of antimicrobials and modulators of antibiotic resistance.

AB - Microorganisms represent a large and still resourceful pool for the discovery of novel compounds to combat antibiotic resistance in human and animal pathogens. The ability of microorganisms to produce structurally diverse volatile compounds has been known for decades, yet their biological functions and antimicrobial activities have only recently attracted attention. Various studies revealed that microbial volatiles can act as infochemicals in long-distance cross-kingdom communication as well as antimicrobials in competition and predation. Here, we review recent insights into the natural functions and modes of action of microbial volatiles and discuss their potential as a new class of antimicrobials and modulators of antibiotic resistance.

KW - NIOO

U2 - 10.1016/j.mib.2018.02.011

DO - 10.1016/j.mib.2018.02.011

M3 - Article

SN - 1369-5274

VL - 45

SP - 84

EP - 91

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

IS - October

ER -