Heterogeneity in mRNA Translation

Stijn Sonneveld; Bram M P Verhagen; Marvin E Tanenbaum

doi:10.1016/j.tcb.2020.04.008

Heterogeneity in mRNA Translation

Stijn Sonneveld, Bram M P Verhagen, Marvin E Tanenbaum

Hubrecht Institute

Research output: Contribution to journal/periodical › Book/Film/Article review › Scientific

69 Citations (Scopus)

Abstract

During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a single gene in an individual cell; multiple different polypeptides can be produced from a single mRNA molecule and the rate of translation can vary in both space and time. However, whether translational heterogeneity serves an important cellular function, or rather predominantly represents gene expression 'noise' remains an open question. In this review, we discuss the molecular basis and potential functions of such translational heterogeneity.

Original language	English
Pages (from-to)	606-618
Number of pages	13
Journal	Trends in Cell Biology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.tcb.2020.04.008
Publication status	Published - Aug 2020

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abstract = "During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a single gene in an individual cell; multiple different polypeptides can be produced from a single mRNA molecule and the rate of translation can vary in both space and time. However, whether translational heterogeneity serves an important cellular function, or rather predominantly represents gene expression 'noise' remains an open question. In this review, we discuss the molecular basis and potential functions of such translational heterogeneity.",

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AB - During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a single gene in an individual cell; multiple different polypeptides can be produced from a single mRNA molecule and the rate of translation can vary in both space and time. However, whether translational heterogeneity serves an important cellular function, or rather predominantly represents gene expression 'noise' remains an open question. In this review, we discuss the molecular basis and potential functions of such translational heterogeneity.

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DO - 10.1016/j.tcb.2020.04.008

M3 - Book/Film/Article review

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JO - Trends in Cell Biology

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Heterogeneity in mRNA Translation

Abstract

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