High prevalence of parent-reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy

Lindsay M H Steur, Martha A Grootenhuis, Eus J W Van Someren, Natasha K A Van Eijkelenburg, Inge M Van der Sluis, Natasja Dors, Cor Van den Bos, Wim J E Tissing, Gertjan J L Kaspers, Raphaële R L Van Litsenburg

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Abstract

OBJECTIVE: To assess sleep problems (prevalence and predictors) in pediatric patients with acute lymphoblastic leukemia (ALL) after the most intensive phase of therapy (induction).

METHODS: Patients (≥2 years) treated according to the Dutch ALL-11 protocol were included. Sleep was measured using parent-reports and self-reports (Children's Sleep Habits Questionnaire; CSHQ) and actigraphy. Parental sleep (Medical Outcome Study Sleep Scale) and distress and parenting problems (Distress Thermometer for Parents) were assessed with questionnaires. Z-scores were calculated for total CSHQ scores using age-appropriate scores of healthy Dutch children. The prevalence of sleep problems (defined as a Z-score > 1) in patients with ALL was compared to healthy children (chi-square tests). Actigraphic sleep estimates were collected in healthy Dutch children (n = 86, 2-18 years) for comparison with patients (linear regression). Determinants of parent-reported child sleep (total CSHQ Z-score) were identified with regression models.

RESULTS: Responses were collected for 124 patients (response rate 67%), comprising 123 parent-reports, 34 self-reports, and 69 actigraphy assessments. Parents reported sleep problems in 38.0% of the patients compared to 15.2% in healthy children (P < .001). Patients reported fewer sleep problems themselves: 12.1% compared to 15.8% in healthy children (P = .33). Total time in bed (B (95% CI): 22.89 (9.55-36.22)) and total sleep time (B (95% CI):16.30 (1.40-31.19)), as derived from actigraphy, were significantly longer in patients. More parent-reported child sleep problems were predicted by parenting problems, more parental sleep problems, bedroom sharing, and child's sleep medication use (explained variance: 27.4%).

CONCLUSIONS: Systematic monitoring of child and parental sleep and implementation of effective interventions may be a gateway to improve quality of survival in pediatric ALL.

Original languageEnglish
Pages (from-to)e28165
JournalPediatric blood & cancer
Volume67
DOIs
Publication statusPublished - 2020

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    Steur, L. M. H., Grootenhuis, M. A., Van Someren, E. J. W., Van Eijkelenburg, N. K. A., Van der Sluis, I. M., Dors, N., Van den Bos, C., Tissing, W. J. E., Kaspers, G. J. L., & Van Litsenburg, R. R. L. (2020). High prevalence of parent-reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy. Pediatric blood & cancer, 67, e28165. https://doi.org/10.1002/pbc.28165