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High-frequency microdomain Ca2+ transients and waves during early myelin internode remodeling. / Battefeld, A.; Popovic, M.; de Vries, Sharon I; Kole, M.H.P.

In: Cell Reports, Vol. 26, 05.01.2019, p. 182-191.

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@article{97d2cc3ad3c94218a1ab6057b109ee65,
title = "High-frequency microdomain Ca2+ transients and waves during early myelin internode remodeling.",
abstract = "Ensheathment of axons by myelin is a highly complex and multi-cellular process. Cytosolic calcium (Ca2+) changes in the myelin sheath have beenimplicated in myelin synthesis, but the source of this Ca2+ and the role of neuronal activity is not well understood. Using one-photon Ca2+ imaging,we investigated myelin sheath formation in the mouse somatosensory cortex and found a high rate of spontaneous microdomain Ca2+ transientsand large-amplitude Ca2+ waves propagating along the internode. The frequency of Ca2+ transients and waves rapidly declines with maturation and reactivates during remyelination. Unexpectedly, myelin microdomain Ca2+ transients occur independent of neuronal action potential generation or network activity but are nearly completely abolished when the mitochondrial permeability transition pores are blocked. These findings are supported by the discoveryof mitochondria organelles in non-compacted myelin. Together, the results suggest that myelin microdomain Ca2+ signals are cell-autonomouslydriven by high activity of mitochondria during myelin remodeling.",
author = "A. Battefeld and M. Popovic and {de Vries}, {Sharon I} and M.H.P. Kole",
year = "2019",
month = "1",
day = "5",
doi = "10.1016/j.celrep.2018.12.039",
language = "English",
volume = "26",
pages = "182--191",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",

}

RIS

TY - JOUR

T1 - High-frequency microdomain Ca2+ transients and waves during early myelin internode remodeling.

AU - Battefeld,A.

AU - Popovic,M.

AU - de Vries,Sharon I

AU - Kole,M.H.P.

PY - 2019/1/5

Y1 - 2019/1/5

N2 - Ensheathment of axons by myelin is a highly complex and multi-cellular process. Cytosolic calcium (Ca2+) changes in the myelin sheath have beenimplicated in myelin synthesis, but the source of this Ca2+ and the role of neuronal activity is not well understood. Using one-photon Ca2+ imaging,we investigated myelin sheath formation in the mouse somatosensory cortex and found a high rate of spontaneous microdomain Ca2+ transientsand large-amplitude Ca2+ waves propagating along the internode. The frequency of Ca2+ transients and waves rapidly declines with maturation and reactivates during remyelination. Unexpectedly, myelin microdomain Ca2+ transients occur independent of neuronal action potential generation or network activity but are nearly completely abolished when the mitochondrial permeability transition pores are blocked. These findings are supported by the discoveryof mitochondria organelles in non-compacted myelin. Together, the results suggest that myelin microdomain Ca2+ signals are cell-autonomouslydriven by high activity of mitochondria during myelin remodeling.

AB - Ensheathment of axons by myelin is a highly complex and multi-cellular process. Cytosolic calcium (Ca2+) changes in the myelin sheath have beenimplicated in myelin synthesis, but the source of this Ca2+ and the role of neuronal activity is not well understood. Using one-photon Ca2+ imaging,we investigated myelin sheath formation in the mouse somatosensory cortex and found a high rate of spontaneous microdomain Ca2+ transientsand large-amplitude Ca2+ waves propagating along the internode. The frequency of Ca2+ transients and waves rapidly declines with maturation and reactivates during remyelination. Unexpectedly, myelin microdomain Ca2+ transients occur independent of neuronal action potential generation or network activity but are nearly completely abolished when the mitochondrial permeability transition pores are blocked. These findings are supported by the discoveryof mitochondria organelles in non-compacted myelin. Together, the results suggest that myelin microdomain Ca2+ signals are cell-autonomouslydriven by high activity of mitochondria during myelin remodeling.

U2 - 10.1016/j.celrep.2018.12.039

DO - 10.1016/j.celrep.2018.12.039

M3 - Article

VL - 26

SP - 182

EP - 191

JO - Cell Reports

T2 - Cell Reports

JF - Cell Reports

SN - 2211-1247

ER -

ID: 9290316