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Human Brain Slice Culture : A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds. / Qi, Xin-Rui; Verwer, Ronald W H; Bao, Ai-Min; Balesar, Rawien A; Luchetti, Sabina; Zhou, Jiang-Ning; Swaab, Dick F.

In: Neuroscience Bulletin, Vol. 35, 2019, p. 244-252.

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@article{d1ad765ef4994e49a45b4797998ee297,
title = "Human Brain Slice Culture: A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds",
abstract = "Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed. In vivo studies of animal models and in vitro studies of cell lines/primary cell cultures may provide useful tools to study certain aspects of brain disorders. However, discrepancies among these studies or unsuccessful translation from animal/cell studies to human/clinical studies often occur, because these models generally represent only some symptoms of a neuropsychiatric disorder rather than the complete disorder. Human brain slice cultures from postmortem tissue or resected tissue from operations have shown that, in vitro, neurons and glia can stay alive for long periods of time, while their morphological and physiological characteristics, and their ability to respond to experimental manipulations are maintained. Human brain slices can thus provide a close representation of neuronal networks in vivo, be a valuable tool for investigation of the basis of neuropsychiatric disorders, and provide a platform for the evaluation of novel pharmacological treatments of human brain diseases. A brain bank needs to provide the necessary infrastructure to bring together donors, hospitals, and researchers who want to investigate human brain slices in cultures of clinically and neuropathologically well-documented material.",
author = "Xin-Rui Qi and Verwer, {Ronald W H} and Ai-Min Bao and Balesar, {Rawien A} and Sabina Luchetti and Jiang-Ning Zhou and Swaab, {Dick F}",
year = "2019",
doi = "10.1007/s12264-018-0328-1",
language = "English",
volume = "35",
pages = "244--252",
journal = "Neuroscience Bulletin",
issn = "1673-7067",
publisher = "Science Press",

}

RIS

TY - JOUR

T1 - Human Brain Slice Culture

T2 - A Useful Tool to Study Brain Disorders and Potential Therapeutic Compounds

AU - Qi, Xin-Rui

AU - Verwer, Ronald W H

AU - Bao, Ai-Min

AU - Balesar, Rawien A

AU - Luchetti, Sabina

AU - Zhou, Jiang-Ning

AU - Swaab, Dick F

PY - 2019

Y1 - 2019

N2 - Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed. In vivo studies of animal models and in vitro studies of cell lines/primary cell cultures may provide useful tools to study certain aspects of brain disorders. However, discrepancies among these studies or unsuccessful translation from animal/cell studies to human/clinical studies often occur, because these models generally represent only some symptoms of a neuropsychiatric disorder rather than the complete disorder. Human brain slice cultures from postmortem tissue or resected tissue from operations have shown that, in vitro, neurons and glia can stay alive for long periods of time, while their morphological and physiological characteristics, and their ability to respond to experimental manipulations are maintained. Human brain slices can thus provide a close representation of neuronal networks in vivo, be a valuable tool for investigation of the basis of neuropsychiatric disorders, and provide a platform for the evaluation of novel pharmacological treatments of human brain diseases. A brain bank needs to provide the necessary infrastructure to bring together donors, hospitals, and researchers who want to investigate human brain slices in cultures of clinically and neuropathologically well-documented material.

AB - Investigating the pathophysiological mechanisms underlying brain disorders is a priority if novel therapeutic strategies are to be developed. In vivo studies of animal models and in vitro studies of cell lines/primary cell cultures may provide useful tools to study certain aspects of brain disorders. However, discrepancies among these studies or unsuccessful translation from animal/cell studies to human/clinical studies often occur, because these models generally represent only some symptoms of a neuropsychiatric disorder rather than the complete disorder. Human brain slice cultures from postmortem tissue or resected tissue from operations have shown that, in vitro, neurons and glia can stay alive for long periods of time, while their morphological and physiological characteristics, and their ability to respond to experimental manipulations are maintained. Human brain slices can thus provide a close representation of neuronal networks in vivo, be a valuable tool for investigation of the basis of neuropsychiatric disorders, and provide a platform for the evaluation of novel pharmacological treatments of human brain diseases. A brain bank needs to provide the necessary infrastructure to bring together donors, hospitals, and researchers who want to investigate human brain slices in cultures of clinically and neuropathologically well-documented material.

U2 - 10.1007/s12264-018-0328-1

DO - 10.1007/s12264-018-0328-1

M3 - Article

VL - 35

SP - 244

EP - 252

JO - Neuroscience Bulletin

JF - Neuroscience Bulletin

SN - 1673-7067

ER -

ID: 9314329