Identical cells with different 3D genomes; cause and consequences?

P.H. Krijger, W. de Laat

Research output: Contribution to journal/periodicalArticleScientificpeer-review

39 Citations (Scopus)


The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We propose a model (dog-on-a-lead model) to understand the principles behind and consequences of cell-specific remote DNA contacts and speculate that cell-specific genome topologies can cause variegated gene expression among otherwise identical cells.
Original languageEnglish
Pages (from-to)191-196
JournalCurrent Opinion in Genetics & Development
Issue number2
Publication statusPublished - 2013


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