If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer

L. Bonapace, J. Wyckoff, T. Oertner, J. van Rheenen, T. Junt, M. Bentires-Alj

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

A fundamental hallmark of cancer is progression to metastasis and the growth of breast cancer metastases in lung, bone, liver and/or brain causes fatal complications. Unfortunately, the cellular and biochemical mechanisms of the metastatic process remain ill-defined. Recent application of intravital multiphoton microscopy (MP-IVM) to image fluorescently labeled cells in mouse models of cancer has allowed dynamic observation of this multi-step process at the cellular and subcellular levels. In this article, we discuss the use of MP-IVM in studies of breast cancer metastasis, as well as surgical techniques for exposing tumors prior to imaging. We also describe a versatile multiphoton microscope for imaging tumor-stroma interactions.
Original languageEnglish
Pages (from-to)125-129
JournalJournal of Mammary Gland Biology and Neoplasia
Volume17
Issue number2
DOIs
Publication statusPublished - 2012

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