In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex

H. Badali, H. Fakhim, F. Zarei, M. Nabili, A. Vaezi, N. Poorzad, S. Dolatabadi, H. Mirhendi

    Research output: Contribution to journal/periodicalArticleScientificpeer-review

    Abstract

    Black aspergilli, particularly Aspergillus niger and A. tubingensis, are the most common etiological agents of otomycosis followed by onychomycosis, pulmonary aspergillosis and aspergilloma. However, so far there is no systematic study on their antifungal susceptibility profiles. A collection of 124 clinical and environmental species of black aspergilli consisted of A. niger, A. tubingensis, A. uvarum. A. acidus and A. sydowii were verified by DNA sequencing of the partial beta-tubulin gene. MICs of amphotericin B, itraconazole, voriconazole, posaconazole, and MECs of caspofungin were performed based on CLSI M38-A2. Posaconazole and caspofungin had the lowest MIC range (0.016-0.125 A mu g/ml and 0.008-0.031 A mu g/ml, respectively), followed by amphotericin B (0.25-4 A mu g/ml), voriconazole (0.125-16 A mu g/ml) and itraconazole (0.25 to > 16) in an increasing order. Some strains of A. niger showed high MIC value for itraconazole and voriconazole (> 16 A mu g/ml), in contrast only environmental isolates of A. tubingensis had high itraconazole MICs (> 16 A mu g/ml). These results confirm that posaconazole and caspofungin are potential drugs for treatment of aspergillosis due to opportunistic agents of Aspergillus Nigri complex. However, in vivo efficacy remains to be determined.
    Original languageEnglish
    Pages (from-to)235-240
    Number of pages6
    JournalMycopathologia
    Volume181
    Issue number3-4
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Aspergillus Nigri complex In vitro susceptibility Partial beta-tubulin (BTU) azole resistance black aspergilli section nigri fumigatus susceptibilities onychomycosis otomycosis

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