TY - JOUR
T1 - Inferring the Evolutionary History of Your Favorite Protein
T2 - A Guide for Molecular Biologists
AU - van Hooff, Jolien J E
AU - Tromer, Eelco
AU - van Dam, Teunis J P
AU - Kops, Geert J P L
AU - Snel, Berend
N1 - © The Authors. Bio Essays Published by WILEY Periodicals, Inc.
PY - 2019/5
Y1 - 2019/5
N2 - Comparative genomics has proven a fruitful approach to acquire many functional and evolutionary insights into core cellular processes. Here it is argued that in order to perform accurate and interesting comparative genomics, one first and foremost has to be able to recognize, postulate, and revise different evolutionary scenarios. After all, these studies lack a simple protocol, due to different proteins having different evolutionary dynamics and demanding different approaches. The authors here discuss this challenge from a practical (what are the observations?) and conceptual (how do these indicate a specific evolutionary scenario?) viewpoint, with the aim to guide investigators who want to analyze the evolution of their protein(s) of interest. By sharing how the authors draft, test, and update such a scenario and how it directs their investigations, the authors hope to illuminate how to execute molecular evolution studies and how to interpret them. Also see the video abstract here https://youtu.be/VCt3l2pbdbQ.
AB - Comparative genomics has proven a fruitful approach to acquire many functional and evolutionary insights into core cellular processes. Here it is argued that in order to perform accurate and interesting comparative genomics, one first and foremost has to be able to recognize, postulate, and revise different evolutionary scenarios. After all, these studies lack a simple protocol, due to different proteins having different evolutionary dynamics and demanding different approaches. The authors here discuss this challenge from a practical (what are the observations?) and conceptual (how do these indicate a specific evolutionary scenario?) viewpoint, with the aim to guide investigators who want to analyze the evolution of their protein(s) of interest. By sharing how the authors draft, test, and update such a scenario and how it directs their investigations, the authors hope to illuminate how to execute molecular evolution studies and how to interpret them. Also see the video abstract here https://youtu.be/VCt3l2pbdbQ.
U2 - 10.1002/bies.201900006
DO - 10.1002/bies.201900006
M3 - Article
C2 - 31026339
SN - 0265-9247
VL - 41
SP - e1900006
JO - BioEssays
JF - BioEssays
IS - 5
ER -