Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

V.S. Li, H. Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review


The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.
Original languageEnglish
Pages (from-to)110-112
JournalCurrent Biology
Issue number3
Publication statusPublished - 2013


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