Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

V.S. Li; H. Clevers

doi:10.1016/j.cub.2012.12.021

Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

V.S. Li, H. Clevers

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

15 Citations (Scopus)

Abstract

The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

Original language	English
Pages (from-to)	110-112
Journal	Current Biology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.cub.2012.12.021
Publication status	Published - 2013

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10.1016/j.cub.2012.12.021

Cite this

@article{1d59a13d93714f89a7ca14818c73b8c3,

title = "Intestinal regeneration: YAP-tumor suppressor and oncoprotein?",

abstract = "The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.",

author = "V.S. Li and H. Clevers",

note = "Reporting year: 2013",

year = "2013",

doi = "10.1016/j.cub.2012.12.021",

language = "English",

volume = "23",

pages = "110--112",

journal = "Current Biology",

issn = "0960-9822",