Intravital characterization of tumor cell migration in pancreatic cancer

TY - JOUR

T1 - Intravital characterization of tumor cell migration in pancreatic cancer

AU - Beerling, Evelyne

AU - Oosterom, Ilse

AU - Voest, Emile E

AU - Lolkema, Martijn P

AU - van Rheenen, Jacco

PY - 2016

Y1 - 2016

N2 - Curing pancreatic cancer is difficult as metastases often determine the poor clinical outcome. To gain more insight into the metastatic behavior of pancreatic cancer cells, we characterized migratory cells in primary pancreatic tumors using intravital microscopy. We visualized the migratory behavior of primary tumor cells of a genetically engineered pancreatic cancer mouse model and found that pancreatic tumor cells migrate with a mesenchymal morphology as single individual cells or collectively as a stream of non-cohesive single motile cells. These findings may improve our ability to conceive treatments that block metastatic behavior.

AB - Curing pancreatic cancer is difficult as metastases often determine the poor clinical outcome. To gain more insight into the metastatic behavior of pancreatic cancer cells, we characterized migratory cells in primary pancreatic tumors using intravital microscopy. We visualized the migratory behavior of primary tumor cells of a genetically engineered pancreatic cancer mouse model and found that pancreatic tumor cells migrate with a mesenchymal morphology as single individual cells or collectively as a stream of non-cohesive single motile cells. These findings may improve our ability to conceive treatments that block metastatic behavior.

KW - Journal Article

U2 - 10.1080/21659087.2016.1261773

DO - 10.1080/21659087.2016.1261773

M3 - Article

C2 - 28243522

SN - 2165-9079

VL - 5

SP - e1261773

JO - IntraVital

JF - IntraVital

IS - 3

ER -