Invasive and Non-invasive Neurostimulation for OCD

Isidoor O Bergfeld, Eva Dijkstra, Ilse Graat, Pelle de Koning, Bastijn J G van den Boom, Tara Arbab, Nienke Vulink, Damiaan Denys, Ingo Willuhn, Roel J T Mocking

Research output: Contribution to journal/periodicalArticleScientificpeer-review

20 Citations (Scopus)


It becomes increasingly clear that (non-)invasive neurostimulation is an effective treatment for obsessive-compulsive disorder (OCD). In this chapter we review the available evidence on techniques and targets, clinical results including a meta-analysis, mechanisms of action, and animal research. We focus on deep brain stimulation (DBS), but also cover non-invasive neurostimulation including transcranial magnetic stimulation (TMS). Data shows that most DBS studies target the ventral capsule/ventral striatum (VC/VS), with an overall 76% response rate in treatment-refractory OCD. Also TMS holds clinical promise. Increased insight in the normalizing effects of neurostimulation on cortico-striatal-thalamic-cortical (CSTC) loops - through neuroimaging and animal research - provides novel opportunities to further optimize treatment strategies. Advancing clinical implementation of neurostimulation techniques is essential to ameliorate the lives of the many treatment-refractory OCD patients.

Original languageEnglish
Pages (from-to)399-436
JournalCurrent Topics in Behavioral Neurosciences
Publication statusPublished - Jan 2021


Dive into the research topics of 'Invasive and Non-invasive Neurostimulation for OCD'. Together they form a unique fingerprint.

Cite this