Lamina Associated Domains and Gene Regulation in Development and Cancer

Silke J A Lochs; Samy Kefalopoulou; Jop Kind

doi:10.3390/cells8030271

Lamina Associated Domains and Gene Regulation in Development and Cancer

Silke J A Lochs, Samy Kefalopoulou, Jop Kind

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

48 Citations (Scopus)

Abstract

The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowly transcribed, and enriched for repressive histone modifications. LADs are dynamic structures that shift spatial positioning in accordance with cell-type specific gene expression changes during differentiation and development. Furthermore, recent studies have linked the disruption of LADs and alterations in the epigenome with the onset of diseases such as cancer. Here we focus on the role of LADs and the NL in gene regulation during development and cancer.

Original language	English
Journal	Cells
Volume	8
Issue number	3
DOIs	https://doi.org/10.3390/cells8030271
Publication status	Published - 21 Mar 2019

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10.3390/cells8030271

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abstract = "The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowly transcribed, and enriched for repressive histone modifications. LADs are dynamic structures that shift spatial positioning in accordance with cell-type specific gene expression changes during differentiation and development. Furthermore, recent studies have linked the disruption of LADs and alterations in the epigenome with the onset of diseases such as cancer. Here we focus on the role of LADs and the NL in gene regulation during development and cancer.",

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AU - Kefalopoulou, Samy

AU - Kind, Jop

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AB - The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowly transcribed, and enriched for repressive histone modifications. LADs are dynamic structures that shift spatial positioning in accordance with cell-type specific gene expression changes during differentiation and development. Furthermore, recent studies have linked the disruption of LADs and alterations in the epigenome with the onset of diseases such as cancer. Here we focus on the role of LADs and the NL in gene regulation during development and cancer.

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SN - 2073-4409

VL - 8

JO - Cells

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Lamina Associated Domains and Gene Regulation in Development and Cancer

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