Standard

Learning of anticipatory responses in single neurons of the human medial temporal lobe. / Reddy, Leila; Poncet, Marlene; Self, Matthew W; Peters, Judith C; Douw, Linda; van Dellen, Edwin; Claus, Steven; Reijneveld, Jaap C; Baayen, Johannes C; Roelfsema, Pieter R.

In: Nature Communications, Vol. 6, 2015, p. 8556.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

Reddy, L, Poncet, M, Self, MW, Peters, JC, Douw, L, van Dellen, E, Claus, S, Reijneveld, JC, Baayen, JC & Roelfsema, PR 2015, 'Learning of anticipatory responses in single neurons of the human medial temporal lobe' Nature Communications, vol. 6, pp. 8556. DOI: 10.1038/ncomms9556

APA

Vancouver

Reddy L, Poncet M, Self MW, Peters JC, Douw L, van Dellen E et al. Learning of anticipatory responses in single neurons of the human medial temporal lobe. Nature Communications. 2015;6:8556. Available from, DOI: 10.1038/ncomms9556

Author

Reddy, Leila ; Poncet, Marlene ; Self, Matthew W ; Peters, Judith C ; Douw, Linda ; van Dellen, Edwin ; Claus, Steven ; Reijneveld, Jaap C ; Baayen, Johannes C ; Roelfsema, Pieter R. / Learning of anticipatory responses in single neurons of the human medial temporal lobe. In: Nature Communications. 2015 ; Vol. 6. pp. 8556

BibTeX

@article{3f031903aa764354a6b4b3791dd7b9ec,
title = "Learning of anticipatory responses in single neurons of the human medial temporal lobe",
abstract = "Neuronal processes underlying the formation of new associations in the human brain are not yet well understood. Here human participants, implanted with depth electrodes in the brain, learned arbitrary associations between images presented in an ordered, predictable sequence. During learning we recorded from medial temporal lobe (MTL) neurons that responded to at least one of the pictures in the sequence (the preferred stimulus). We report that as a result of learning, single MTL neurons show asymmetric shifts in activity and start firing earlier in the sequence in anticipation of their preferred stimulus. These effects appear relatively early in learning, after only 11 exposures to the stimulus sequence. The anticipatory neuronal responses emerge while the subjects became faster in reporting the next item in the sequence. These results demonstrate flexible representations that could support learning of new associations between stimuli in a sequence, in single neurons in the human MTL.",
author = "Leila Reddy and Marlene Poncet and Self, {Matthew W} and Peters, {Judith C} and Linda Douw and {van Dellen}, Edwin and Steven Claus and Reijneveld, {Jaap C} and Baayen, {Johannes C} and Roelfsema, {Pieter R}",
year = "2015",
doi = "10.1038/ncomms9556",
language = "English",
volume = "6",
pages = "8556",
journal = "Nature Communications",
issn = "2041-1723",

}

RIS

TY - JOUR

T1 - Learning of anticipatory responses in single neurons of the human medial temporal lobe

AU - Reddy,Leila

AU - Poncet,Marlene

AU - Self,Matthew W

AU - Peters,Judith C

AU - Douw,Linda

AU - van Dellen,Edwin

AU - Claus,Steven

AU - Reijneveld,Jaap C

AU - Baayen,Johannes C

AU - Roelfsema,Pieter R

PY - 2015

Y1 - 2015

N2 - Neuronal processes underlying the formation of new associations in the human brain are not yet well understood. Here human participants, implanted with depth electrodes in the brain, learned arbitrary associations between images presented in an ordered, predictable sequence. During learning we recorded from medial temporal lobe (MTL) neurons that responded to at least one of the pictures in the sequence (the preferred stimulus). We report that as a result of learning, single MTL neurons show asymmetric shifts in activity and start firing earlier in the sequence in anticipation of their preferred stimulus. These effects appear relatively early in learning, after only 11 exposures to the stimulus sequence. The anticipatory neuronal responses emerge while the subjects became faster in reporting the next item in the sequence. These results demonstrate flexible representations that could support learning of new associations between stimuli in a sequence, in single neurons in the human MTL.

AB - Neuronal processes underlying the formation of new associations in the human brain are not yet well understood. Here human participants, implanted with depth electrodes in the brain, learned arbitrary associations between images presented in an ordered, predictable sequence. During learning we recorded from medial temporal lobe (MTL) neurons that responded to at least one of the pictures in the sequence (the preferred stimulus). We report that as a result of learning, single MTL neurons show asymmetric shifts in activity and start firing earlier in the sequence in anticipation of their preferred stimulus. These effects appear relatively early in learning, after only 11 exposures to the stimulus sequence. The anticipatory neuronal responses emerge while the subjects became faster in reporting the next item in the sequence. These results demonstrate flexible representations that could support learning of new associations between stimuli in a sequence, in single neurons in the human MTL.

U2 - 10.1038/ncomms9556

DO - 10.1038/ncomms9556

M3 - Article

VL - 6

SP - 8556

JO - Nature Communications

T2 - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

ID: 1544959