Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

H.J.G. Snippert; A. Haegebarth; M. Kasper; V. Jaks; J.H. van Es; N. Barker; M.L. van de Wetering; M.M.W. van den Born; H.L. Begthel; R.G.J. Vries; D.E. Stange; R. Toftgard; H. Clevers

doi:10.1126/science.1184733

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

H.J.G. Snippert, A. Haegebarth, M. Kasper, V. Jaks, J.H. van Es, N. Barker, M.L. van de Wetering, M.M.W. van den Born, H.L. Begthel, R.G.J. Vries, D.E. Stange, R. Toftgard, H. Clevers

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

635 Citations (Scopus)

Abstract

Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.

Original language	English
Pages (from-to)	1385-1389
Journal	Science Magazine
Volume	327
Issue number	5971
DOIs	https://doi.org/10.1126/science.1184733
Publication status	Published - 2010

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Snippert, H. J. G., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M. L., van den Born, M. M. W., Begthel, H. L., Vries, R. G. J., Stange, D. E., Toftgard, R., & Clevers, H. (2010). Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science Magazine, 327(5971), 1385-1389. https://doi.org/10.1126/science.1184733

@article{8203d79ec822490ea75b98c70beeab78,

title = "Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin",

abstract = "Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.",

author = "H.J.G. Snippert and A. Haegebarth and M. Kasper and V. Jaks and {van Es}, J.H. and N. Barker and {van de Wetering}, M.L. and {van den Born}, M.M.W. and H.L. Begthel and R.G.J. Vries and D.E. Stange and R. Toftgard and H. Clevers",

note = "Reporting year: 2010 Metis note: 327/5971/1385 [pii]",

year = "2010",

doi = "10.1126/science.1184733",

language = "English",

volume = "327",

pages = "1385--1389",

journal = "Science Magazine",

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publisher = "American Association for the Advancement of Science (AAAS)",

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TY - JOUR

T1 - Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

AU - Snippert, H.J.G.

AU - Haegebarth, A.

AU - Kasper, M.

AU - Jaks, V.

AU - van Es, J.H.

AU - Barker, N.

AU - van de Wetering, M.L.

AU - van den Born, M.M.W.

AU - Begthel, H.L.

AU - Vries, R.G.J.

AU - Stange, D.E.

AU - Toftgard, R.

AU - Clevers, H.

N1 - Reporting year: 2010 Metis note: 327/5971/1385 [pii]

PY - 2010

Y1 - 2010

N2 - Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.

AB - Mammalian epidermis consists of three self-renewing compartments: the hair follicle, the sebaceous gland, and the interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative of the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland, and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, whereas contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.

U2 - 10.1126/science.1184733

DO - 10.1126/science.1184733

M3 - Article

SN - 0036-8075

VL - 327

SP - 1385

EP - 1389

JO - Science Magazine

JF - Science Magazine

IS - 5971

ER -

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin

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