Lumbar drainage for the treatment of refractory intracranial hypertension in HIV-negative cryptococcal meningitis

Qilong Zhang, Hang Li, Keming Zhang, Amir Arastehfar, Farnaz Daneshnia, Wenjie Fang, Peijuan He, Weifeng Kuang, Guoqiang Jiang, Min Chen, Teun Boekhout, Shuai Li, Weiwei Jiang, Wanqing Liao, Weihua Pan

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Aim: This study aims to evaluate lumbar drainage (LD) for controlling refractory intracranial hypertension among non-HIV cryptococcal meningitis patients. Patients & methods: A case-control study was designed to compare LD (case) with repeated lumbar puncture (control). Results: Both LD and repeated lumbar puncture can efficiently control refractory intracranial hypertension. LD group showed better clinical symptom remission, such as lower rate of headache, vision disorders, signs of meningeal irritation and conscious disturbance, than control group. LD group was reported with higher intracranial pressure reduction (173.75 ± 17.72 mmH2O) than those among control group (113.50 ± 14.94 mmH2O; p < 0.05). Conclusion: LD is an effective and safe alternative to control refractory intracranial hypertension in HIV-negative cryptococcal meningitis patients.

Original languageEnglish
Pages (from-to)859-866
Number of pages8
JournalFuture Microbiology
Volume14
DOIs
Publication statusPublished - Jul 2019

Fingerprint

Dive into the research topics of 'Lumbar drainage for the treatment of refractory intracranial hypertension in HIV-negative cryptococcal meningitis'. Together they form a unique fingerprint.

Cite this