Lymphatic vascular morphogenesis in development, physiology, and disease

S. Schulte-Merker, A. Sabine, T.V. Petrova

Research output: Contribution to journal/periodicalArticleScientificpeer-review

269 Downloads (Pure)


The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases. [KEYWORDS: Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology/metabolism/ physiopathology, Lymphedema/genetics/metabolism/ physiopathology, Morphogenesis]
Original languageEnglish
Pages (from-to)607-618
JournalJournal of Cell Biology
Issue number4
Publication statusPublished - 2011


Dive into the research topics of 'Lymphatic vascular morphogenesis in development, physiology, and disease'. Together they form a unique fingerprint.

Cite this