Lymphatic vascular morphogenesis in development, physiology, and disease

S. Schulte-Merker; A. Sabine; T.V. Petrova

doi:10.1083/jcb.201012094

Lymphatic vascular morphogenesis in development, physiology, and disease

S. Schulte-Merker, A. Sabine, T.V. Petrova

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

335 Citations (Scopus)

398 Downloads (Pure)

Abstract

The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases. [KEYWORDS: Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology/metabolism/ physiopathology, Lymphedema/genetics/metabolism/ physiopathology, Morphogenesis]

Original language	English
Pages (from-to)	607-618
Journal	Journal of Cell Biology
Volume	193
Issue number	4
DOIs	https://doi.org/10.1083/jcb.201012094
Publication status	Published - 2011

Access to Document

10.1083/jcb.201012094

PDF
(c) KNAW - Koninklijke Nederlandse Akademie van Wetenschappen, 2011
Final published version, 1.99 MBLicence: CC BY-NC-SA

Cite this

@article{5e6175e238e04bdb90bea5773c6f73bb,

title = "Lymphatic vascular morphogenesis in development, physiology, and disease",

abstract = "The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases. [KEYWORDS: Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology/metabolism/ physiopathology, Lymphedema/genetics/metabolism/ physiopathology, Morphogenesis]",

author = "S. Schulte-Merker and A. Sabine and T.V. Petrova",

note = "Reporting year: 2011",

year = "2011",

doi = "10.1083/jcb.201012094",

language = "English",

volume = "193",

pages = "607--618",

journal = "Journal of Cell Biology",

issn = "0021-9525",

publisher = "Rockefeller University Press",

number = "4",

}

TY - JOUR

T1 - Lymphatic vascular morphogenesis in development, physiology, and disease

AU - Schulte-Merker, S.

AU - Sabine, A.

AU - Petrova, T.V.

N1 - Reporting year: 2011

PY - 2011

Y1 - 2011

N2 - The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases. [KEYWORDS: Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology/metabolism/ physiopathology, Lymphedema/genetics/metabolism/ physiopathology, Morphogenesis]

AB - The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases. [KEYWORDS: Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology/metabolism/ physiopathology, Lymphedema/genetics/metabolism/ physiopathology, Morphogenesis]

U2 - 10.1083/jcb.201012094

DO - 10.1083/jcb.201012094

M3 - Article

SN - 0021-9525

VL - 193

SP - 607

EP - 618

JO - Journal of Cell Biology

JF - Journal of Cell Biology

IS - 4

ER -

Lymphatic vascular morphogenesis in development, physiology, and disease

Abstract

Access to Document

Fingerprint

Cite this