Mechanotransduction: vinculin provides stability when tension rises

E. Spanjaard; J. de Rooij

doi:10.1016/j.cub.2013.01.020

Mechanotransduction: vinculin provides stability when tension rises

E. Spanjaard, J. de Rooij

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

20 Citations (Scopus)

Abstract

By beautiful imaging and state-of-the-art experiments, vinculin is established to be a central switch in mechanotransduction at integrin-based focal adhesions. Cycles of tension-regulated vinculin switching control focal adhesion dynamics and signaling to enable polarized cell migration and alignment.

Original language	English
Pages (from-to)	159-161
Journal	Current Biology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.cub.2013.01.020
Publication status	Published - 2013

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title = "Mechanotransduction: vinculin provides stability when tension rises",

abstract = "By beautiful imaging and state-of-the-art experiments, vinculin is established to be a central switch in mechanotransduction at integrin-based focal adhesions. Cycles of tension-regulated vinculin switching control focal adhesion dynamics and signaling to enable polarized cell migration and alignment.",

author = "E. Spanjaard and {de Rooij}, J.",

note = "Reporting year: 2013",

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AB - By beautiful imaging and state-of-the-art experiments, vinculin is established to be a central switch in mechanotransduction at integrin-based focal adhesions. Cycles of tension-regulated vinculin switching control focal adhesion dynamics and signaling to enable polarized cell migration and alignment.

U2 - 10.1016/j.cub.2013.01.020

DO - 10.1016/j.cub.2013.01.020

M3 - Article

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VL - 23

SP - 159

EP - 161

JO - Current Biology

JF - Current Biology

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Mechanotransduction: vinculin provides stability when tension rises

Abstract

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