Mechanotransduction: vinculin provides stability when tension rises

E. Spanjaard, J. de Rooij

Research output: Contribution to journal/periodicalArticleScientificpeer-review


By beautiful imaging and state-of-the-art experiments, vinculin is established to be a central switch in mechanotransduction at integrin-based focal adhesions. Cycles of tension-regulated vinculin switching control focal adhesion dynamics and signaling to enable polarized cell migration and alignment.
Original languageEnglish
Pages (from-to)159-161
JournalCurrent Biology
Issue number4
Publication statusPublished - 2013


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