Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

Angelica Aguilera-Gomez, Catherine Rabouille

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

Original languageEnglish
Pages (from-to)310-317
Number of pages8
JournalDevelopmental Biology
Volume428
Issue number2
DOIs
Publication statusPublished - 15 Aug 2017

Keywords

  • Animals
  • Cell Compartmentation
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Genes, Insect
  • Membranes
  • Metabolic Networks and Pathways
  • Models, Biological
  • Oocytes
  • Organelles
  • SEC Translocation Channels
  • Transforming Growth Factor alpha
  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila'. Together they form a unique fingerprint.

Cite this