Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

Original languageEnglish
Pages (from-to)310-317
Number of pages8
JournalDevelopmental Biology
Issue number2
StatePublished - 15 Aug 2017

    Research areas

  • Animals, Cell Compartmentation, Drosophila Proteins, Drosophila melanogaster, Female, Genes, Insect, Membranes, Metabolic Networks and Pathways, Models, Biological, Oocytes, Organelles, SEC Translocation Channels, Transforming Growth Factor alpha, Journal Article, Review, Research Support, Non-U.S. Gov't

ID: 6033816