MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance

Sander P J Joosten, Tomohiro Mizutani, Marcel Spaargaren, Hans Clevers, Steven T Pals

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Original languageEnglish
Pages (from-to)1153-1155.e1
Issue number4
Publication statusPublished - Oct 2019


  • Antineoplastic Agents/pharmacology
  • Cell Line, Tumor
  • Cell Proliferation/drug effects
  • Colorectal Neoplasms/drug therapy
  • Drug Resistance, Neoplasm/drug effects
  • ErbB Receptors/antagonists & inhibitors
  • Gefitinib/pharmacology
  • Genes, APC
  • Humans
  • Intestinal Mucosa/drug effects
  • Mutation
  • Neoplastic Stem Cells/drug effects
  • Protein Kinase Inhibitors/pharmacology
  • Proto-Oncogene Proteins c-met/antagonists & inhibitors
  • Pyrazines/pharmacology
  • Signal Transduction
  • Triazines/pharmacology

Cite this