Microbiota controls the homeostasis of glial cells in the gut lamina propria

Panagiotis S Kabouridis, Reena Lasrado, Sarah McCallum, Song Hui Chng, Hugo J Snippert, Hans Clevers, Sven Pettersson, Vassilis Pachnis

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota.

Original languageEnglish
Pages (from-to)289-95
Number of pages7
JournalNeuron
Volume85
Issue number2
DOIs
Publication statusPublished - 21 Jan 2015

Keywords

  • Animals
  • Cell Differentiation
  • Homeostasis
  • Intestinal Mucosa
  • Intestines
  • Mice
  • Microbiota
  • Mucous Membrane
  • Neuroglia
  • Submucous Plexus

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