Microbiota controls the homeostasis of glial cells in the gut lamina propria

TY - JOUR

T1 - Microbiota controls the homeostasis of glial cells in the gut lamina propria

AU - Kabouridis, Panagiotis S

AU - Lasrado, Reena

AU - McCallum, Sarah

AU - Chng, Song Hui

AU - Snippert, Hugo J

AU - Clevers, Hans

AU - Pettersson, Sven

AU - Pachnis, Vassilis

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/1/21

Y1 - 2015/1/21

N2 - The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota.

AB - The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota.

KW - Animals

KW - Cell Differentiation

KW - Homeostasis

KW - Intestinal Mucosa

KW - Intestines

KW - Mice

KW - Microbiota

KW - Mucous Membrane

KW - Neuroglia

KW - Submucous Plexus

U2 - 10.1016/j.neuron.2014.12.037

DO - 10.1016/j.neuron.2014.12.037

M3 - Article

C2 - 25578362

SN - 0896-6273

VL - 85

SP - 289

EP - 295

JO - Neuron

JF - Neuron

IS - 2

ER -