Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets

Elahe Hadavi; Jeroen Leijten; Marten Engelse; Eelco de Koning; Pascal Jonkheijm; Marcel Karperien; Aart van Apeldoorn

doi:10.1089/ten.TEC.2018.0336

Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets

Elahe Hadavi, Jeroen Leijten, Marten Engelse, Eelco de Koning, Pascal Jonkheijm, Marcel Karperien, Aart van Apeldoorn

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

12 Citations (Scopus)

Abstract

IMPACT STATEMENT: This research deals with finding a proper bioengineering strategy to improve the outcome of islets transplantation for treatment of type 1 diabetes. It is focused on the mimicking of islet extracellular matrix niche in microwell islet delivery devices to improve their endocrine function.

Original language	English
Pages (from-to)	71-81
Number of pages	11
Journal	Tissue Engineering - Part C: Methods
Volume	25
Issue number	2
DOIs	https://doi.org/10.1089/ten.TEC.2018.0336
Publication status	Published - Feb 2019

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10.1089/ten.TEC.2018.0336

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title = "Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets",

abstract = "IMPACT STATEMENT: This research deals with finding a proper bioengineering strategy to improve the outcome of islets transplantation for treatment of type 1 diabetes. It is focused on the mimicking of islet extracellular matrix niche in microwell islet delivery devices to improve their endocrine function.",

author = "Elahe Hadavi and Jeroen Leijten and Marten Engelse and {de Koning}, Eelco and Pascal Jonkheijm and Marcel Karperien and {van Apeldoorn}, Aart",

year = "2019",

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doi = "10.1089/ten.TEC.2018.0336",

language = "English",

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AU - Hadavi, Elahe

AU - Leijten, Jeroen

AU - Engelse, Marten

AU - de Koning, Eelco

AU - Jonkheijm, Pascal

AU - Karperien, Marcel

AU - van Apeldoorn, Aart

PY - 2019/2

Y1 - 2019/2

N2 - IMPACT STATEMENT: This research deals with finding a proper bioengineering strategy to improve the outcome of islets transplantation for treatment of type 1 diabetes. It is focused on the mimicking of islet extracellular matrix niche in microwell islet delivery devices to improve their endocrine function.

AB - IMPACT STATEMENT: This research deals with finding a proper bioengineering strategy to improve the outcome of islets transplantation for treatment of type 1 diabetes. It is focused on the mimicking of islet extracellular matrix niche in microwell islet delivery devices to improve their endocrine function.

U2 - 10.1089/ten.TEC.2018.0336

DO - 10.1089/ten.TEC.2018.0336

M3 - Article

C2 - 30632461

SN - 1937-3384

VL - 25

SP - 71

EP - 81

JO - Tissue Engineering - Part C: Methods

JF - Tissue Engineering - Part C: Methods

IS - 2

ER -

Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets

Abstract

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