Model organoids provide new research opportunities for ductal pancreatic cancer

TY - JOUR

T1 - Model organoids provide new research opportunities for ductal pancreatic cancer

AU - Boj, Sylvia F

AU - Hwang, Chang-Il

AU - Baker, Lindsey A

AU - Engle, Dannielle D

AU - Tuveson, David A

AU - Clevers, Hans

PY - 2016/1

Y1 - 2016/1

N2 - We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

AB - We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

U2 - 10.1080/23723556.2015.1014757

DO - 10.1080/23723556.2015.1014757

M3 - Article

C2 - 27308531

SN - 2372-3556

VL - 3

SP - e1014757

JO - Molecular & Cellular Oncology

JF - Molecular & Cellular Oncology

IS - 1

ER -