Model organoids provide new research opportunities for ductal pancreatic cancer

Sylvia F Boj, Chang-Il Hwang, Lindsey A Baker, Dannielle D Engle, David A Tuveson, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

Original languageEnglish
Pages (from-to)e1014757
JournalMolecular & Cellular Oncology
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 2016

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