Modeling Development and Disease with Organoids

TY - JOUR

T1 - Modeling Development and Disease with Organoids

AU - Clevers, Hans

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/6/16

Y1 - 2016/6/16

N2 - Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored.

AB - Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored.

U2 - 10.1016/j.cell.2016.05.082

DO - 10.1016/j.cell.2016.05.082

M3 - Article

C2 - 27315476

SN - 0092-8674

VL - 165

SP - 1586

EP - 1597

JO - Cell

JF - Cell

IS - 7

ER -