Modeling motor neuron disease: the matter of time

Mandana Arbab; Susanne Baars; Niels Geijsen

doi:10.1016/j.tins.2014.07.008

Modeling motor neuron disease: the matter of time

Mandana Arbab, Susanne Baars, Niels Geijsen

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

25 Citations (Scopus)

Abstract

Stem cell technologies have created new opportunities to generate unlimited numbers of human neurons in the lab and study neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Although some disease hallmarks have been reported in patient-derived stem cell models, it is proving more difficult to recapitulate the full phenotypic extent of these disorders. The problem with these stem cell models lies in the disparity between the advanced age of onset of neurodegenerative disorders and the embryonic nature of the in vitro derived cell types. In this review we discuss experimental methods of in vitro aging of neural cell types as a means to elicit late-onset symptoms in induced pluripotent stem cell (iPSC) models of neurodegenerative disease.

Original language	English
Pages (from-to)	642-52
Number of pages	11
Journal	Trends in Neurosciences
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/j.tins.2014.07.008
Publication status	Published - Nov 2014

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10.1016/j.tins.2014.07.008

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abstract = "Stem cell technologies have created new opportunities to generate unlimited numbers of human neurons in the lab and study neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Although some disease hallmarks have been reported in patient-derived stem cell models, it is proving more difficult to recapitulate the full phenotypic extent of these disorders. The problem with these stem cell models lies in the disparity between the advanced age of onset of neurodegenerative disorders and the embryonic nature of the in vitro derived cell types. In this review we discuss experimental methods of in vitro aging of neural cell types as a means to elicit late-onset symptoms in induced pluripotent stem cell (iPSC) models of neurodegenerative disease.",

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Modeling motor neuron disease: the matter of time

Abstract

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