Modeling motor neuron disease: the matter of time

Mandana Arbab, Susanne Baars, Niels Geijsen

Research output: Contribution to journal/periodicalArticleScientificpeer-review


Stem cell technologies have created new opportunities to generate unlimited numbers of human neurons in the lab and study neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Although some disease hallmarks have been reported in patient-derived stem cell models, it is proving more difficult to recapitulate the full phenotypic extent of these disorders. The problem with these stem cell models lies in the disparity between the advanced age of onset of neurodegenerative disorders and the embryonic nature of the in vitro derived cell types. In this review we discuss experimental methods of in vitro aging of neural cell types as a means to elicit late-onset symptoms in induced pluripotent stem cell (iPSC) models of neurodegenerative disease.

Original languageEnglish
Pages (from-to)642-52
Number of pages11
JournalTrends in Neurosciences
Issue number11
Publication statusPublished - Nov 2014


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