Modeling pancreatic cancer with organoids

Lindsey A Baker, Hervé Tiriac, Hans Clevers, David A Tuveson

Research output: Contribution to journal/periodicalArticleScientificpeer-review

143 Citations (Scopus)


Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new treatment and diagnostic approaches are urgently needed. In order for such breakthroughs to be discovered, researchers require systems that accurately model the development and biology of PDA. While cell lines, genetically engineered murine models, and xenografts have all led to valuable clinical insights, organotypic culture models have emerged as tractable systems to recapitulate the complex three-dimensional organization of PDA. Recently, multiple methods for modeling PDA using organoids have been reported. This review aims to summarize these organoid methods in the context of other PDA models. While each model system has unique benefits and drawbacks, ultimately, organoids hold special promise for the development of personalized medicine approaches.

Original languageEnglish
Pages (from-to)176-190
Number of pages15
JournalTrends in Cancer
Issue number4
Publication statusPublished - Apr 2016


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