Modulation of the secretory pathway by amino-acid starvation

Wessel van Leeuwen, Felix van der Krift, Catherine Rabouille

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

As a major anabolic pathway, the secretory pathway needs to adapt to the demands of the surrounding environment and responds to different exogenous signals and stimuli. In this context, the transport in the early secretory pathway from the endoplasmic reticulum (ER) to the Golgi apparatus appears particularly regulated. For instance, protein export from the ER is critically stimulated by growth factors. Conversely, nutrient starvation also modulates functions of the early secretory pathway in multiple ways. In this review, we focus on amino-acid starvation and how the function of the early secretory pathway is redirected to fuel autophagy, how the ER exit sites are remodeled into novel cytoprotective stress assemblies, and how secretion is modulated in vivo in starving organisms. With the increasingly exciting knowledge on mechanistic target of rapamycin complex 1 (mTORC1), the major nutrient sensor, it is also a good moment to establish how the modulation of the secretory pathway by amino-acid restriction intersects with this major signaling hub.

Original languageEnglish
Pages (from-to)2261-2271
Number of pages11
JournalJournal of Cell Biology
Volume217
Issue number7
DOIs
Publication statusPublished - 02 Jul 2018

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