Standard

Network of nuclear receptor ligands in multiple sclerosis : Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules. / Rolf, Linda; Damoiseaux, Jan; Hupperts, Raymond; Huitinga, I.; Smolders, Joost.

In: Autoimmunity Reviews, Vol. 15, 06.07.2016, p. 900-910.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

APA

Vancouver

Author

Rolf, Linda ; Damoiseaux, Jan ; Hupperts, Raymond ; Huitinga, I. ; Smolders, Joost. / Network of nuclear receptor ligands in multiple sclerosis : Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules. In: Autoimmunity Reviews. 2016 ; Vol. 15. pp. 900-910.

BibTeX

@article{c7372d01cf8c466faaec47236447cf20,
title = "Network of nuclear receptor ligands in multiple sclerosis: Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules",
abstract = "Sex steroids, corticosteroids and vitamin D3-derived molecules have all been subject to experimental studies and clinical trials in a plethora of autoimmune diseases. These molecules are all derived from cholesterol metabolites and are ligands for nuclear receptors. Ligation of these receptors results in direct regulation of multiple gene transcription involved in general homeostatic and adaptation networks, including the immune system. Indeed, the distinct ligands affect the function of both myeloid and lymphoid cells, eventually resulting in a less pro-inflammatory immune response which is considered beneficial in autoimmune diseases. Next to the immune system, also the central nervous system is prone to regulation by these nuclear receptor ligands. Understanding of the intricate interactions between sex-steroids, corticosteroids and vitamin D3 metabolites, on the one hand, and the immune and central nervous system, on the other hand, may reveal novel approaches to utilize these nuclear receptor ligands to full extent as putative treatments in multiple sclerosis, the prototypic immune-driven disease of the central nervous system.",
author = "Linda Rolf and Jan Damoiseaux and Raymond Hupperts and I. Huitinga and Joost Smolders",
note = "Copyright {\circledC} 2016. Published by Elsevier B.V.",
year = "2016",
month = "7",
day = "6",
doi = "10.1016/j.autrev.2016.07.002",
language = "English",
volume = "15",
pages = "900--910",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier B.V.",

}

RIS

TY - JOUR

T1 - Network of nuclear receptor ligands in multiple sclerosis

T2 - Common pathways and interactions of sex-steroids, corticosteroids and vitamin D3-derived molecules

AU - Rolf, Linda

AU - Damoiseaux, Jan

AU - Hupperts, Raymond

AU - Huitinga, I.

AU - Smolders, Joost

N1 - Copyright © 2016. Published by Elsevier B.V.

PY - 2016/7/6

Y1 - 2016/7/6

N2 - Sex steroids, corticosteroids and vitamin D3-derived molecules have all been subject to experimental studies and clinical trials in a plethora of autoimmune diseases. These molecules are all derived from cholesterol metabolites and are ligands for nuclear receptors. Ligation of these receptors results in direct regulation of multiple gene transcription involved in general homeostatic and adaptation networks, including the immune system. Indeed, the distinct ligands affect the function of both myeloid and lymphoid cells, eventually resulting in a less pro-inflammatory immune response which is considered beneficial in autoimmune diseases. Next to the immune system, also the central nervous system is prone to regulation by these nuclear receptor ligands. Understanding of the intricate interactions between sex-steroids, corticosteroids and vitamin D3 metabolites, on the one hand, and the immune and central nervous system, on the other hand, may reveal novel approaches to utilize these nuclear receptor ligands to full extent as putative treatments in multiple sclerosis, the prototypic immune-driven disease of the central nervous system.

AB - Sex steroids, corticosteroids and vitamin D3-derived molecules have all been subject to experimental studies and clinical trials in a plethora of autoimmune diseases. These molecules are all derived from cholesterol metabolites and are ligands for nuclear receptors. Ligation of these receptors results in direct regulation of multiple gene transcription involved in general homeostatic and adaptation networks, including the immune system. Indeed, the distinct ligands affect the function of both myeloid and lymphoid cells, eventually resulting in a less pro-inflammatory immune response which is considered beneficial in autoimmune diseases. Next to the immune system, also the central nervous system is prone to regulation by these nuclear receptor ligands. Understanding of the intricate interactions between sex-steroids, corticosteroids and vitamin D3 metabolites, on the one hand, and the immune and central nervous system, on the other hand, may reveal novel approaches to utilize these nuclear receptor ligands to full extent as putative treatments in multiple sclerosis, the prototypic immune-driven disease of the central nervous system.

U2 - 10.1016/j.autrev.2016.07.002

DO - 10.1016/j.autrev.2016.07.002

M3 - Article

VL - 15

SP - 900

EP - 910

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

ER -

ID: 2202002