TY - JOUR
T1 - Neuromodulation in obsessive-compulsive disorder
AU - Bais, Melisse
AU - Figee, Martijn
AU - Denys, D.
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014/9
Y1 - 2014/9
N2 - Neuromodulation techniques in obsessive-compulsive disorder (OCD) involve electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS). This article reviews the available literature on the efficacy and applicability of these techniques in OCD. ECT is used for the treatment of comorbid depression or psychosis. One case report on tDCS showed no effects in OCD. Low-frequency TMS provides significant but mostly transient improvement of obsessive-compulsive symptoms. DBS shows a response rate of 60% in open and sham-controlled studies. In OCD, it can be concluded that DBS, although more invasive, is the most efficacious technique.
AB - Neuromodulation techniques in obsessive-compulsive disorder (OCD) involve electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS). This article reviews the available literature on the efficacy and applicability of these techniques in OCD. ECT is used for the treatment of comorbid depression or psychosis. One case report on tDCS showed no effects in OCD. Low-frequency TMS provides significant but mostly transient improvement of obsessive-compulsive symptoms. DBS shows a response rate of 60% in open and sham-controlled studies. In OCD, it can be concluded that DBS, although more invasive, is the most efficacious technique.
U2 - 10.1016/j.psc.2014.06.003
DO - 10.1016/j.psc.2014.06.003
M3 - Article
C2 - 25150569
SN - 0193-953X
VL - 37
SP - 393
EP - 413
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
IS - 3
ER -