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Neuropathology and cognitive performance in self-reported cognitively healthy centenarians. / Ganz, Andrea B; Beker, Nina; Hulsman, Marc; Sikkes, Sietske A M; Netherlands Brain Bank; Scheltens, Philip; Smit, August B; Rozemuller, Annemieke J M; Hoozemans, Jeroen J M; Holstege, Henne.

In: Acta neuropathologica communications, Vol. 6, No. 1, 64, 23.07.2018.

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Harvard

Ganz, AB, Beker, N, Hulsman, M, Sikkes, SAM, Netherlands Brain Bank, Scheltens, P, Smit, AB, Rozemuller, AJM, Hoozemans, JJM & Holstege, H 2018, 'Neuropathology and cognitive performance in self-reported cognitively healthy centenarians' Acta neuropathologica communications, vol. 6, no. 1, 64. https://doi.org/10.1186/s40478-018-0558-5

APA

Ganz, A. B., Beker, N., Hulsman, M., Sikkes, S. A. M., Netherlands Brain Bank, Scheltens, P., ... Holstege, H. (2018). Neuropathology and cognitive performance in self-reported cognitively healthy centenarians. Acta neuropathologica communications, 6(1), [64]. https://doi.org/10.1186/s40478-018-0558-5

Vancouver

Ganz AB, Beker N, Hulsman M, Sikkes SAM, Netherlands Brain Bank, Scheltens P et al. Neuropathology and cognitive performance in self-reported cognitively healthy centenarians. Acta neuropathologica communications. 2018 Jul 23;6(1). 64. https://doi.org/10.1186/s40478-018-0558-5

Author

Ganz, Andrea B ; Beker, Nina ; Hulsman, Marc ; Sikkes, Sietske A M ; Netherlands Brain Bank ; Scheltens, Philip ; Smit, August B ; Rozemuller, Annemieke J M ; Hoozemans, Jeroen J M ; Holstege, Henne. / Neuropathology and cognitive performance in self-reported cognitively healthy centenarians. In: Acta neuropathologica communications. 2018 ; Vol. 6, No. 1.

BibTeX

@article{46a1eec8d1714de29314740b32ce2beb,
title = "Neuropathology and cognitive performance in self-reported cognitively healthy centenarians",
abstract = "With aging, the incidence of neuropathological hallmarks of neurodegenerative diseases increases in the brains of cognitively healthy individuals. It is currently unclear to what extent these hallmarks associate with symptoms of disease at extreme ages. Forty centenarians from the 100-plus Study cohort donated their brain. Centenarians self-reported to be cognitively healthy at baseline, which was confirmed by a proxy. Objective ante-mortem measurements of cognitive performance were associated with the prevalence, distribution and quantity of age- and AD-related neuropathological hallmarks. Despite self-reported cognitive health, objective neuropsychological testing suggested varying levels of ante-mortem cognitive functioning. Post-mortem, we found that neuropathological hallmarks related to age and neurodegenerative diseases, such as Aβ and Tau pathology, as well as atherosclerosis, were abundantly present in most or all centenarians, whereas Lewy body and pTDP-43 pathology were scarce. We observed that increased pathology loads correlated across pathology subtypes, and an overall trend of higher pathology loads to associate with a lower cognitive test performance. This trend was carried especially by the presence of neurofibrillary tangles (NFTs) and granulovacuolar degeneration (GVD) and to a lesser extent by Aβ-associated pathologies. Cerebral Amyloid Angiopathy (CAA) specifically associated with lower executive functioning in the centenarians. In conclusion, we find that while the centenarians in this cohort escaped or delayed cognitive impairment until extreme ages, their brains reveal varying levels of disease-associated neuropathological hallmarks, some of which associate with cognitive performance.",
keywords = "Journal Article",
author = "Ganz, {Andrea B} and Nina Beker and Marc Hulsman and Sikkes, {Sietske A M} and {Netherlands Brain Bank} and Philip Scheltens and Smit, {August B} and Rozemuller, {Annemieke J M} and Hoozemans, {Jeroen J M} and Henne Holstege",
year = "2018",
month = "7",
day = "23",
doi = "10.1186/s40478-018-0558-5",
language = "English",
volume = "6",
journal = "Acta neuropathologica communications",
issn = "2051-5960",
publisher = "BioMed Central",
number = "1",

}

RIS

TY - JOUR

T1 - Neuropathology and cognitive performance in self-reported cognitively healthy centenarians

AU - Ganz, Andrea B

AU - Beker, Nina

AU - Hulsman, Marc

AU - Sikkes, Sietske A M

AU - Netherlands Brain Bank, null

AU - Scheltens, Philip

AU - Smit, August B

AU - Rozemuller, Annemieke J M

AU - Hoozemans, Jeroen J M

AU - Holstege, Henne

PY - 2018/7/23

Y1 - 2018/7/23

N2 - With aging, the incidence of neuropathological hallmarks of neurodegenerative diseases increases in the brains of cognitively healthy individuals. It is currently unclear to what extent these hallmarks associate with symptoms of disease at extreme ages. Forty centenarians from the 100-plus Study cohort donated their brain. Centenarians self-reported to be cognitively healthy at baseline, which was confirmed by a proxy. Objective ante-mortem measurements of cognitive performance were associated with the prevalence, distribution and quantity of age- and AD-related neuropathological hallmarks. Despite self-reported cognitive health, objective neuropsychological testing suggested varying levels of ante-mortem cognitive functioning. Post-mortem, we found that neuropathological hallmarks related to age and neurodegenerative diseases, such as Aβ and Tau pathology, as well as atherosclerosis, were abundantly present in most or all centenarians, whereas Lewy body and pTDP-43 pathology were scarce. We observed that increased pathology loads correlated across pathology subtypes, and an overall trend of higher pathology loads to associate with a lower cognitive test performance. This trend was carried especially by the presence of neurofibrillary tangles (NFTs) and granulovacuolar degeneration (GVD) and to a lesser extent by Aβ-associated pathologies. Cerebral Amyloid Angiopathy (CAA) specifically associated with lower executive functioning in the centenarians. In conclusion, we find that while the centenarians in this cohort escaped or delayed cognitive impairment until extreme ages, their brains reveal varying levels of disease-associated neuropathological hallmarks, some of which associate with cognitive performance.

AB - With aging, the incidence of neuropathological hallmarks of neurodegenerative diseases increases in the brains of cognitively healthy individuals. It is currently unclear to what extent these hallmarks associate with symptoms of disease at extreme ages. Forty centenarians from the 100-plus Study cohort donated their brain. Centenarians self-reported to be cognitively healthy at baseline, which was confirmed by a proxy. Objective ante-mortem measurements of cognitive performance were associated with the prevalence, distribution and quantity of age- and AD-related neuropathological hallmarks. Despite self-reported cognitive health, objective neuropsychological testing suggested varying levels of ante-mortem cognitive functioning. Post-mortem, we found that neuropathological hallmarks related to age and neurodegenerative diseases, such as Aβ and Tau pathology, as well as atherosclerosis, were abundantly present in most or all centenarians, whereas Lewy body and pTDP-43 pathology were scarce. We observed that increased pathology loads correlated across pathology subtypes, and an overall trend of higher pathology loads to associate with a lower cognitive test performance. This trend was carried especially by the presence of neurofibrillary tangles (NFTs) and granulovacuolar degeneration (GVD) and to a lesser extent by Aβ-associated pathologies. Cerebral Amyloid Angiopathy (CAA) specifically associated with lower executive functioning in the centenarians. In conclusion, we find that while the centenarians in this cohort escaped or delayed cognitive impairment until extreme ages, their brains reveal varying levels of disease-associated neuropathological hallmarks, some of which associate with cognitive performance.

KW - Journal Article

U2 - 10.1186/s40478-018-0558-5

DO - 10.1186/s40478-018-0558-5

M3 - Article

VL - 6

JO - Acta neuropathologica communications

JF - Acta neuropathologica communications

SN - 2051-5960

IS - 1

M1 - 64

ER -

ID: 7053143