New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

Naomi A Fineberg; Samuel R Chamberlain; Anna E Goudriaan; Dan J Stein; Louk J M J Vanderschuren; Claire M Gillan; Sameer Shekar; Philip A P M Gorwood; Valerie Voon; Sharon Morein-Zamir; D. Denys; Barbara J Sahakian; F Gerard Moeller; Trevor W Robbins; Marc N Potenza

doi:10.1017/S1092852913000801

New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

Naomi A Fineberg, Samuel R Chamberlain, Anna E Goudriaan, Dan J Stein, Louk J M J Vanderschuren, Claire M Gillan, Sameer Shekar, Philip A P M Gorwood, Valerie Voon, Sharon Morein-Zamir, D. Denys, Barbara J Sahakian, F Gerard Moeller, Trevor W Robbins, Marc N Potenza

Netherlands Institute for Neuroscience (NIN)

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

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Abstract

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

Original language	English
Pages (from-to)	69-89
Number of pages	21
Journal	CNS Spectrums
Volume	19
Issue number	1
DOIs	https://doi.org/10.1017/S1092852913000801
Publication status	Published - Feb 2014

Keywords

Animals
Behavior, Addictive
Cognitive Science
Compulsive Behavior
Humans
Impulsive Behavior
Prognosis
Substance-Related Disorders

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Fineberg, N. A., Chamberlain, S. R., Goudriaan, A. E., Stein, D. J., Vanderschuren, L. J. M. J., Gillan, C. M., Shekar, S., Gorwood, P. A. P. M., Voon, V., Morein-Zamir, S., Denys, D., Sahakian, B. J., Moeller, F. G., Robbins, T. W., & Potenza, M. N. (2014). New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS Spectrums, 19(1), 69-89. https://doi.org/10.1017/S1092852913000801

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abstract = "Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.",

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year = "2014",

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doi = "10.1017/S1092852913000801",

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Fineberg, NA, Chamberlain, SR, Goudriaan, AE, Stein, DJ, Vanderschuren, LJMJ, Gillan, CM, Shekar, S, Gorwood, PAPM, Voon, V, Morein-Zamir, S, Denys, D, Sahakian, BJ, Moeller, FG, Robbins, TW & Potenza, MN 2014, 'New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity', CNS Spectrums, vol. 19, no. 1, pp. 69-89. https://doi.org/10.1017/S1092852913000801

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T2 - clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

AU - Fineberg, Naomi A

AU - Chamberlain, Samuel R

AU - Goudriaan, Anna E

AU - Stein, Dan J

AU - Vanderschuren, Louk J M J

AU - Gillan, Claire M

AU - Shekar, Sameer

AU - Gorwood, Philip A P M

AU - Voon, Valerie

AU - Morein-Zamir, Sharon

AU - Denys, D.

AU - Sahakian, Barbara J

AU - Moeller, F Gerard

AU - Robbins, Trevor W

AU - Potenza, Marc N

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AB - Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

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KW - Behavior, Addictive

KW - Cognitive Science

KW - Compulsive Behavior

KW - Humans

KW - Impulsive Behavior

KW - Prognosis

KW - Substance-Related Disorders

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DO - 10.1017/S1092852913000801

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EP - 89

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ER -

New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

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