New insights in dermatophyte research

TY - JOUR

T1 - New insights in dermatophyte research

AU - Gräser, Yvonne

AU - Monod, Michel

AU - Bouchara, Jean Philippe

AU - Dukik, Karolina

AU - Nenoff, Pietro

AU - Kargl, Alexandra

AU - Kupsch, Christiane

AU - Zhan, Ping

AU - Packeu, Ann

AU - Chaturvedi, Vishnu

AU - De Hoog, Sybren

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Dermatophyte research has renewed interest because of changing human floras with changing socioeconomic conditions, and because of severe chronic infections in patients with congenital immune disorders. Main taxonomic traits at the generic level have changed considerably, and now fine-tuning at the species level with state-of-the-art technology has become urgent. Research on virulence factors focuses on secreted proteases now has support in genome data. It is speculated that most protease families are used for degrading hard keratin during nitrogen recycling in the environment, while others, such as Sub6 may have emerged as a result of ancestral gene duplication, and are likely to have specific roles during infection. Virulence may differ between mating partners of the same species and concepts of zoo- and anthropophily may require revision in some recently redefined species. Many of these questions benefit from international cooperation and exchange of materials. The aim of the ISHAM Working Group Dermatophytes aims to stimulate and coordinate international networking on these fungi.

AB - Dermatophyte research has renewed interest because of changing human floras with changing socioeconomic conditions, and because of severe chronic infections in patients with congenital immune disorders. Main taxonomic traits at the generic level have changed considerably, and now fine-tuning at the species level with state-of-the-art technology has become urgent. Research on virulence factors focuses on secreted proteases now has support in genome data. It is speculated that most protease families are used for degrading hard keratin during nitrogen recycling in the environment, while others, such as Sub6 may have emerged as a result of ancestral gene duplication, and are likely to have specific roles during infection. Virulence may differ between mating partners of the same species and concepts of zoo- and anthropophily may require revision in some recently redefined species. Many of these questions benefit from international cooperation and exchange of materials. The aim of the ISHAM Working Group Dermatophytes aims to stimulate and coordinate international networking on these fungi.

KW - CARD9

KW - dermatophyte phylogeny

KW - secreted protease

KW - taxonomy

KW - virulence

KW - zoonoses

U2 - 10.1093/mmy/myx141

DO - 10.1093/mmy/myx141

M3 - Article

C2 - 29538740

SN - 1369-3786

VL - 56

SP - S2-S9

JO - Medical Mycology

JF - Medical Mycology

ER -