No link of serotonin 2C receptor editing to serotonin transporter genotype

R. Lyddon; E. Cuppen; V. Haroutunian; L.J. Siever; S. Dracheva

doi:10.1097/WNR.0b013e32834052f0

No link of serotonin 2C receptor editing to serotonin transporter genotype

R. Lyddon, E. Cuppen, V. Haroutunian, L.J. Siever, S. Dracheva

Hubrecht Institute

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

3 Citations (Scopus)

Abstract

RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.

Original language	English
Pages (from-to)	1080-1084
Journal	NeuroReport
Volume	21
Issue number	17
DOIs	https://doi.org/10.1097/WNR.0b013e32834052f0
Publication status	Published - 2010

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title = "No link of serotonin 2C receptor editing to serotonin transporter genotype",

abstract = "RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.",

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AU - Cuppen, E.

AU - Haroutunian, V.

AU - Siever, L.J.

AU - Dracheva, S.

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AB - RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.

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EP - 1084

JO - NeuroReport

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No link of serotonin 2C receptor editing to serotonin transporter genotype

Abstract

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