DOI

The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.

Original languageEnglish
Pages (from-to)2604-5
Number of pages2
JournalEMBO Journal
Volume33
Issue number22
DOI
StatePublished - 18 Nov 2014

ID: 885502