Abstract
The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.
| Original language | English |
|---|---|
| Pages (from-to) | 2604-5 |
| Number of pages | 2 |
| Journal | EMBO Journal |
| Volume | 33 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 18 Nov 2014 |