Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani, Yoshiyuki Tsukamoto, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

Original languageEnglish
Pages (from-to)1505-1507
Number of pages3
JournalJournal of Cell Biology
Volume216
Issue number6
DOIs
Publication statusPublished - 05 Jun 2017

Keywords

  • Animals
  • Humans
  • Mice, Transgenic
  • Neoplasms
  • Oncogenes
  • Organoids
  • Signal Transduction
  • Journal Article

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