Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani, Yoshiyuki Tsukamoto, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review


Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

Original languageEnglish
Pages (from-to)1505-1507
Number of pages3
JournalJournal of Cell Biology
Issue number6
Publication statusPublished - 05 Jun 2017


  • Animals
  • Humans
  • Mice, Transgenic
  • Neoplasms
  • Oncogenes
  • Organoids
  • Signal Transduction
  • Journal Article


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