Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani; Yoshiyuki Tsukamoto; Hans Clevers

doi:10.1083/jcb.201704014

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani
, Yoshiyuki Tsukamoto
, Hans Clevers

Hubrecht Institute

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, 3584CT Utrecht, Netherlands. [email protected] [email protected].
Department of Molecular Pathology, Faculty of Medicine, Oita University, 879-5593 Yufu, Japan.

Research output: Contribution to journal/periodical › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

Original language	English
Pages (from-to)	1505-1507
Number of pages	3
Journal	Journal of Cell Biology
Volume	216
Issue number	6
DOIs	https://doi.org/10.1083/jcb.201704014
Publication status	Published - 05 Jun 2017

Keywords

Animals
Humans
Mice, Transgenic
Neoplasms
Oncogenes
Organoids
Signal Transduction
Journal Article

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10.1083/jcb.201704014

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title = "Oncogene-inducible organoids as a miniature platform to assess cancer characteristics",

abstract = "Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.",

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AU - Tsukamoto, Yoshiyuki

AU - Clevers, Hans

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KW - Animals

KW - Humans

KW - Mice, Transgenic

KW - Neoplasms

KW - Oncogenes

KW - Organoids

KW - Signal Transduction

KW - Journal Article

U2 - 10.1083/jcb.201704014

DO - 10.1083/jcb.201704014

M3 - Article

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JF - Journal of Cell Biology

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ER -

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Abstract

Keywords

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