Organoid culture systems to study host-pathogen interactions

Devanjali Dutta, Hans Clevers

Research output: Contribution to journal/periodicalArticleScientificpeer-review

Abstract

Recent advances in host-microbe interaction studies in organoid cultures have shown great promise and have laid the foundation for much more refined future studies using these systems. Modeling of Zika virus (ZIKV) infection in cerebral organoids have helped us understand its association with microcephaly. Similarly, the pathogenesis of bacterial (Helicobacter pylori, Clostridium difficile) and viral (Norovirus, Rotaviruses) infections have been precisely dissected in organoid cultures. Additionally, direct associations between microbial colonization of tissues and diseases like cancer have also been deciphered. Here we discuss the most recent and striking studies on host-microbe interactions in organoid cultures, highlighting various methods which can be used for developing microbe-organoid co-culture systems.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalCurrent Opinion in Immunology
Volume48
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Journal Article
  • Review

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